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  • Title: Clonidine suppression of bradycardia induced by gigantocellular reticular nucleus in the cat.
    Author: Kuo JS, Chan SH.
    Journal: Eur J Pharmacol; 1980 Feb; 61(4):393-6. PubMed ID: 7371715.
    Abstract:
    In chloralose-urethane-anesthetized cats, intravertebral injection of clonidine (0.5--4.0 micrograms/kg) elicited a drastic suppression of the bradycardia induced by stimulating the gigantocellular reticular nucleus (GRN). The degree of blockage of GRN-induced cardioinhibtion was related to the time course of the inherent cardiovascular effects of clonidine. It was also dependent upon the dose of the imidazoline compound and the intensity/train pulse frequency of reticular stimulation. It was suggested that the two mechanisms may interact with one another in the brainstem and possible modes of interaction were discussed.
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