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  • Title: [The use of allopurinol in long-term treatments for optimal effect].
    Author: Fenner H.
    Journal: Fortschr Med; 1980 Mar 13; 98(10):(373-6). PubMed ID: 7372221.
    Abstract:
    The importance of allopurinol drug formulation is discussed regarding the relationship between allopurinol-oxipurinol pharmacokinetics and the mechanism of action. The oxipurinol plasma levels were simulated basing on a single dose regimen and an oxipurinol plasma half life of 14 hours. From these data it is evident, that during long term treatment of hyperuricemia and gout a sustained release allopurinol-formulation fulfills the requirement of adequately maintained oxipurinol plasma levels.
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