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  • Title: Effect of serotonin on Y-maze retention and hippocampal protein synthesis in rats.
    Author: Wetzel W, Getsova VM, Jork R, Matthies H.
    Journal: Pharmacol Biochem Behav; 1980 Feb; 12(2):319-22. PubMed ID: 7375496.
    Abstract:
    The effect of serotonin (5-HT) on consolidation of a brightness discrimination reaction was investigated in rats. Five microgram 5-HT, injected intrahippocampally immediately after training, impaired retention of the brightness discrimination tested 24 hr later. In biochemical experiments, leucine incorporation into hippocampal proteins in vivo was 32% inhibited by 5 microgram 5-HT. Leucine incorporation into proteins of hippocampal slices in vitro was decreased by 5 x 10(-5)M 5-HT. The results seem to support Essman's assumption that inhibition of brain protein synthesis by 5-HT may be responsible for the memory impairment. But also some other possibilities for a mechanism of 5-HT amnesia must be discussed.
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