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  • Title: Effects of nitrous oxide on systolic time intervals.
    Author: Eriksen S, Johannsen G, Frost N.
    Journal: Acta Anaesthesiol Scand; 1980; 24(1):74-8. PubMed ID: 7376808.
    Abstract:
    The effects of inhalation of oxygen, nitrous oxide/oxygen and nitrous oxide/nitrogen/oxygen on systolic time intervals (PEP (pre-ejection period) and LVET (left ventricular ejection time) were investigated in eight healthy persons. Nitrous oxide 40%, administered with oxygen or oxygen/nitrogen, prolonged PEP significantly by 25% and 22%, respectively. Inhalation of oxygen also prolonged PEP but to a significantly minor degree. LVET, heart rate and MAP were unchanged during the experiments. Derivatives from the systolic time intervals, i.e. PEP/LVET, I/PEP2 and ejection fraction changed significantly in the nitrous oxide groups. It is concluded that nitrous oxide depresses cardiac performance, to some degree, even when administered at a rather low concentration.
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