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  • Title: Spindle cell cancer of bladder during cyclophosphamide therapy for Wegener's granulomatosis.
    Author: Chasko SB, Keuhnelian JG, Gutowski WT, Gray GF.
    Journal: Am J Surg Pathol; 1980 Apr; 4(2):191-6. PubMed ID: 7377464.
    Abstract:
    A 38-year-old woman with long-standing Wegener's granulomatosis had remission with cyclophosphamide therapy after failure of response to other agents. Severe cystitis with massive blood loss necessitated a cystectomy. The bladder contained an unsuspected neoplasm, histologically resembling leiomyosarcoma, but desmosomes seen on electron-microscopic examination suggested that this was a spindle cell carcinoma. The findings document occurrence of cyclophosphamide related bladder cancer in a patient without a previously diagnosed neoplasm and indicate a need for cytologic monitoring of the bladder in patients requiring therapy with this drug.
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