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  • Title: [P-450 cytochromes and mono-oxygenases. Mechanism of action. Consequences in pharmacology and toxicology (author's transl)].
    Author: Mansuy D.
    Journal: Ann Biol Clin (Paris); 1980; 38(1):19-23. PubMed ID: 7377646.
    Abstract:
    The mechanism of action of mono-oxygenases of the biotransformation system of exogenic compounds is described emphasising two characteristics which are at the root of the implications of this system in pharmacology and toxicology : its non-specificity with regard to substrates and its great chemical reactivity. The consequences of the biotransformation of a drug (modulation of its therapeutic effect, appearance of noxious side-effects due to the formation of reactive metabolites) are illustrated by a few examples. Finally, the various mechanisms by which a drug may modify biotransformation and the effects of a second drug given in association, are analysed.
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