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  • Title: Potentiation of pentobarbitone sleeping time by chloroquine in the rat.
    Author: Ayitey-Smith E.
    Journal: Arch Int Pharmacodyn Ther; 1980 Feb; 243(2):192-6. PubMed ID: 7377893.
    Abstract:
    The effects of chronic administration of chloroquine on pentobarbitone sleeping time was studied in albino rats. Administration of chloroquine (20 mg/kg s.c.) for 21 days significantly increased pentobarbitone sleeping time by 16--105% within that period. A combination of chloroquine (20 mg/kg s.c.) and pentobarbitone (20 mg/kg s.c.) not only antagonised the usual decreased pentobarbitone sleeping time when pentobarbitone is given alone but also increased it by 34--56% within 7--14 days. In chloroquine chronic pretreated rats injection of sub-anaesthetic doses of pentobarbitone (20 mg/kg i.p.) produced anaesthesia for 42.15 +/- 4.6 min while untreated rats became only ataxic. It has been suggested that these effects of chloroquine may be due to a decrease in the metabolism of pentobarbitone in the liver.
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