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  • Title: Interactions between vasopressin and glucagon on ketogenesis and oleate metabolism in isolated hepatocytes from fed rats.
    Author: Williamson DH, Ilic V, Tordoff AF, Ellington EV.
    Journal: Biochem J; 1980 Feb 15; 186(2):621-4. PubMed ID: 7378069.
    Abstract:
    Vasopressin (10nM) inhibited ketogenesis (56%) in hepatocytes from fed rats when oleate (1 mM) was the substrate, but had no effect with butyrate (10mM). The hormone increased the accumulation of lactate and stimulated the esterification of [1(-14)C]oleate (70%). These effects of vasopressin were reversed by glucagon (10 nM). The physiological implications of these findings are discussed.
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