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  • Title: [Intrahepatic circulation of 14C-phenazepam and its metabolites in albino rats].
    Author: Bogatskiĭ AV, Golovenko NIa, Zin'kovskiĭ VG.
    Journal: Biull Eksp Biol Med; 1980; 89(1):27-9. PubMed ID: 7378565.
    Abstract:
    Excretion of phenazepam and its metabolites into the bile and their intrahepatic circulation were studied in experiments on rats, bile donors, who were preliminarily injected 14C-phenazepam (14 mg/kg) intravenously and on recipients who were administered the donor's bile intraduodenally. It was shown that phenazepam (compound I) and its 3-hydroxymetabolite (compound III) are excreted into the bile of the animals. Hydroxyl derivatives are excreted with the bile as glucuronides. Compounds I and III and glucuronide III undergo intrahepatic circulation.
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