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  • Title: Supersensitivity after intraventricular 6-hydroxydopamine: relation to dopamine depletion.
    Author: Zigmond MJ, Stricker EM.
    Journal: Experientia; 1980 Apr 15; 36(4):436-8. PubMed ID: 7379917.
    Abstract:
    6-Hydroxydopamine increased behavioral response to L-DOPA in proportion to the decrease of dopamine (DA) and DA utake in rat striatum. The increase response to apomorphine, however, only occurred after greater than 80% DA loss. Thus, 6-hydroxydopamine may induce postsynaptic changes only following large lesions.
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