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  • Title: [Dysgerminoma in pure gonadal dysgenesis (author's transl)].
    Author: Helpap B, Schwinger E, Spiertz K.
    Journal: Geburtshilfe Frauenheilkd; 1980 Apr; 40(4):381-4. PubMed ID: 7380238.
    Abstract:
    By modern cytogenetic methods gonadal dysgenese are more often and exactly clarified than in former times. The cytogenetic analyses have shown that pure XY gonadal dystenesis is often combined with germ cell tumors. A hypergonadotropic ovarian insufficiency as well as a rapidly growing tumor of the left adnexa were diagnosed in a 26-year old woman. At abdominal hysterectomy and bilateral adnexectomy a dysgerminoma on the left side was found as well as on the right side gonadal stroma and rudiments of the Wolffian duct. Blood lymphocytes showed a 46, XY karyotype. The H-Y antigen determination was a positive intermediary titer as compared with normal female and male controls. The cytogenetic demonstration of a pure gonadal dysgenesis in patients with dysgerminoma is important because bilateral development of tumors may occur. Therefore, hysterectomy with bilateral adnexectomy should be carried out.
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