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  • Title: Spontaneous cytotoxicity of murine cells treated with the interferon inducers BRL 5907 and BRL 10739.
    Author: Cook RM.
    Journal: Immunology; 1980 Feb; 39(2):151-7. PubMed ID: 7380465.
    Abstract:
    The effects of the polyribonucleotide interferon inducers, BRL 5907 and BRL 10739, on the spontaneous cytotoxicity of CBA mouse cells towards the allogeneic lymphoma EL-4, were investigated. Intravenous administration of BRL 5907 and BRL 10739 increased the cytotoxic activity of a non-adherent, theta-negative, surface immunoglobulin-negative cell present in the spleen, but had no effect on cells in the lymph nodes. Spleen cell cytotoxicity was established within 24 h of injection of the polyribonucleotides, but had disappeared by 4 days. In addition, injection of mice with BRL 10739 increased the spontaneous cytotoxicity of a nylon-wool-adherent, theta-positive spleen cell. Intraperitoneal injection of mice with BRL 5907 and BRL 10739 also enhanced the cytotoxic activity of a non-adherent peritoneal exudate cell.
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