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  • Title: Induction of relaxin secretion in nonpregnant women by human chorionic gonadotropin.
    Author: Quagliarello J, Goldsmith L, Steinetz B, Lustig DS, Weiss G.
    Journal: J Clin Endocrinol Metab; 1980 Jul; 51(1):74-7. PubMed ID: 7380995.
    Abstract:
    Five normal women using barrier forms of contraception has serum samples drawn every 2 days during control menstrual cycles. Relaxin was not detectable in their serum. All five subjects then received 2500 IU hCG im every 2 days beginning 8--10 days after presumed ovulation. All had immunoreactive relaxin detectable in serum 2--6 days after the first hCG injection. Relaxin rose to pregnancy levels (range, 0.26--0.62 ng/ml; mean, 0.38 +/- 0.17 ng/ml) by cycle day 31 and then declined before menstruation. Progesterone levels and cycle lengths of relaxin-secreting cycles were significantly higher (P less than 0.05) than control cycles. Three of the five subjects subsequently received 2500 IU hCG im every 2 days commencing 2--3 days after presumed ovulation until menstruation. Relaxin was not detectable in these cycles. hCG can induce relaxin secretion in nonpregnant women. A hCG stimulus which can induce relaxin secretion from an 8- to 10-day-old corpus luteum cannot induce relaxin secretion in a 2- to 3-day-old corpus luteum, suggesting that the age of the human corpus luteum of the menstrual cycle is an important determinant of responsiveness to hCG. Serum samples were drawn every 2 days during control menstrual cycles from 5 healthy women using barrier forms of contraception. Relaxin (a peptide hormone produced by the human corpus luteum of pregnancy) was not detectable in their serum. 2500 IU hCG im were then administered in all subjects every 2 days beginning 8 to 10 days after first hCG injection, rising to pregnancy levels (range, 0.26 to 0.62 ng/ml; mean, 0.38 + or - 0.17 ng/ml) by cycle day 31 and then declining before menstruation. Progesterone levels and cycle lengths of relaxin-secreting cycles were significantly higher (p 0.05) than control cycles. Relaxin was not detectable in 3 of 5 subjects who subsequently received 2500 IU hCG im every 2 days starting 2 to 3 days after presumed ovulation until menstruation. HCG can induce relaxin secretion in nonpregnant women. It is suggested that the age of human corpus luteum of the menstrual cycle is an important determinant of responsiveness to hCG.
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