These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: High-performance liquid chromatographic analysis of griseofulvin in drug substance and solid dosage forms: separation of impurities and metabolites.
    Author: Townley E, Roden P.
    Journal: J Pharm Sci; 1980 May; 69(5):523-6. PubMed ID: 7381735.
    Abstract:
    A high-performance liquid chromatographic (HPLC) system, consisting of a methanol-water (3:2 v/v) mobile phase and a Zorbax CN column with m-phenylphenol as the internal standard, was utilized to determine the purity of griseofulvin bulk drug substance, to assay griseofulvin in powders, tablets, capsules, and boluses, and to separate griseofulvin from its metabolites. The method was tested on commercial griseofulvin samples, griseofulvin tablets, and a mixture of griseofulvin and its metabolites. The HPLC method is compared to a GLC method.
    [Abstract] [Full Text] [Related] [New Search]