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  • Title: [Bronchospasms induced by acetylcholin and free running exercise. A comparison in 50 asthmatic children (author's transl)].
    Author: Rufin P, Benoist MR, Jean R, Scheinmann P, Paupe J.
    Journal: Nouv Presse Med; 1980 Apr 26; 9(19):1357-60. PubMed ID: 7383850.
    Abstract:
    Fifty asthmatic children were tested for cholinergic bronchial sensitivity and subjected to a free running exercise test; 92% of them showed hypersensitivity to acetylcholine challenge, and exercise-induced bronchospasm occurred in 80%. On pooling the results, 98% had a positive response to at least one of the tests. Qualitatively, there was a correlation between exercise-induced bronchospasm and bronchial sensitivity to acetylcholin in 38 of the 50 children. Quantitatively, however, no correlation could be found between the severity of the exercise-induced bronchospasm and the threshold dose of acetylcholin. This could be explained by the fact that the non-immunological spasmogenic mechanisms involved in the two tests are different.
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