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  • Title: Modulating effect by zinc on hepatic lysosomal fragility induced by surface-active agents.
    Author: Pfeiffer CJ, Cho CH.
    Journal: Res Commun Chem Pathol Pharmacol; 1980 Mar; 27(3):587-98. PubMed ID: 7384647.
    Abstract:
    In vitro studies on rat hepatic lysosomal stability, as assessed by release of beta-glucuronidase, were undertaken to demonstrate the comparative influence of surface-active agents which act by various mechanisms. Bile acids, short chain alcohols, acetylsalicylic acid, and Triton X-100 were studied, as well as their interaction with zinc. The detergents and alcohols enhanced release of this acid hydrolase in a dose dependent fashion, but acetylsalicylic acid did not. Zinc antagonized these effects in a non-specific manner. It is postulated that zinc stabilized lysosomes by direct action on the lysosomal membrane, such as by surface protein interactions, but the precise mechanism remains unknown.
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