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  • Title: Long-lasting depletion of striatal dopamine by a single injection of amphetamine in iprindole-treated rats.
    Author: Fuller RW, Hemrick-Luecke S.
    Journal: Science; 1980 Jul 11; 209(4453):305-7. PubMed ID: 7384808.
    Abstract:
    A single injection of amphetamine given to rats treated concurrently with iprindole so that they could not metabolize the amphetamine by para-hydroxylation resulted in a decrease in the concentration of striatal dopamine 1 week later. The decrease was antagonized by amfonelic acid, an inhibitor of uptake into dopamine neurons. The long-lasting depletion of cerebral dopamine by amphetamine may be analogous to the depletion of cerebral serotonin by halogenated derivatives of amphetamine.
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