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  • Title: Complementary methods for evaluating carotid stenosis: a biophysical basis for ocular pulse wave delays.
    Author: Walden R, L'Italien G, Megerman J, Bouchier-Hayes D, Hanel K, Maloney R, Abbott W.
    Journal: Surgery; 1980 Jul; 88(1):162-7. PubMed ID: 7385019.
    Abstract:
    Attempts to noninvasively estimate the significance of carotid arterial stenoses have resulted in a recent technological explosion. Ocular pulse wave timing [oculoplethysmography (OPG) pulse delay] has been strongly promulgated but also criticized on theoretical grounds and for lack of physiologic validation. Audiofrequency analysis of carotid bruits (carotid phonoangiography CPA) has been combined with OPG allegedly to improve accuracy. To evaluate these methods in a controlled model, we studied the effects of graded unilateral stenoses in the canine carotid artery on physiological parameters and associated OPG and CPA recordings. Arterial compliance was calculated from simultaneous diameter and pressure recordings distal to the stenosis. OPG time delay correlated directly with reductions in flow and pressure and with increasing arterial compliance (P less than 0.01). Thus, the delay is caused at least partially by a decreased pulse wave velocity, resulting from the increased compliance distal to stenoses associated with a significant pressure gradient. OPG is most discriminating for stenoses of higher grades. Because bruits arise from flow disturbances that occur even with moderate degrees of stenosis, CPA provides diagnostic information before profound flow reduction occurs. This study illustrates the value of complementary methods for analyzing complex hemodynamic phenomena and provides evidence to support use of the pulse delay concept to diagnose arterial disease.
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