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  • Title: Induction of colonic adenocarcinomas by 1,2-dimethylhydrazine intrarectally administered in rats.
    Author: Markert C, Rogers LW, Chiu JF.
    Journal: Digestion; 1978; 18(3-4):261-5. PubMed ID: 738542.
    Abstract:
    Multiple colorectal adenocarcinomas were found in Sprague-Dawley rats after intrarectal injection of 1,2-dimethylhydrazine (DMH). These lesions along with mild hyperplasia of the surrounding mucosa developed within 34 weeks after either 3 or 8 injections of 250 mg DMH/kg body weight.
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