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  • Title: [Changes in the fibrinogen level and the risk of defibrination after the intra-amniotic instillation of a saline solution used for abortion purposes].
    Author: Atanasov A.
    Journal: Akush Ginekol (Sofiia); 1980; 19(3):206-9. PubMed ID: 7386774.
    Abstract:
    The effects of intraamniotic instillation of saline solution for abortion induction on blood coagulation were studied in 81 women in the 16-24th week of pregnancy. Activity of blood coagulation system was estimated by changes in plasma fibrinogen concentration. Depending upon the time period between saline instillation and the onset of abortion, the women could be divided into 3 groups. Group 1 included 37 women in whom abortion occurred 24 hours after instillation, group 2 consisted of 28 women in whom abortion occurred 24-48 hours after instillation, and group 3 included 16 women in whom abortion occurred 48 hours after saline instillation. The women in all 3 groups showed decrease in fibrinogen concentration within the 1st 24 hours after saline administration. The maximum decrease in fibrinogen concentration was observed in group 1. Fibrinogen concentrations returned to normal values within 48-64 hours after abortion. It was concluded that transient hypofibrinogenemia induced by intraamniotic saline instillation can play a role in the pathogenesis of disseminated intravascular coagulation.
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