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  • Title: [Production of a murine lymphadenosis NK/LY resistant to rubomycin and a comparison of the cellular DNA histograms of the sensitive and resistant lines].
    Author: Prokhorova EV, Merkulova IB, Shelaputina ZF.
    Journal: Antibiotiki; 1980 May; 25(5):370-4. PubMed ID: 7387132.
    Abstract:
    Lymphadenosis NK/LY resistant to rubomycin was obtained on its repeated cultivation in mice treated with the antibiotic. The rubomycin resistance was stable and preserved for a long period of time when the line was repeatedly cultivated in mice not exposed to the antibiotic. The tumor cells resistant to rubomycin acquired resistance to olivomycin. DNA histograms of the tumor cells obtained by means of impulse cytophotometry provided determination of the tumor sensitivity and resistance to antitumor agents. It is recommended that impulse cytophotometry be used for the screening of antitumor drugs and development of their administration regimen.
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