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  • Title: Studies on antihyperlipidemic agents. I. Synthesis and hypolipidemic activities of phenoxyphenyl alkanoic acid derivatives.
    Author: Kawamatsu Y, Saraie T, Imamiya E, Nishikawa K, Hamuro Y.
    Journal: Arzneimittelforschung; 1980; 30(3):454-9. PubMed ID: 7387754.
    Abstract:
    The alkanoic acids containing phenoxyphenyl moiety at omega-position were prepared and tested for hypolipidemic property. Some of the compounds showed hypoglycemic activity besides hypolipidemic one. Further study on the selected compound, 3-[4-(4-chlorophenoxy)benzoyl] propionic acid (8) revealed that it increased insulin sensitivity of adipose tissue of obese and diabetic mice (KKAY). The structure-activity relationship was discussed briefly.
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