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  • Title: [Na+ and Cl- ion concentration gradients between the external medium and tissues of the rabbit gallbladder wall].
    Author: Iaremenko MS.
    Journal: Biull Eksp Biol Med; 1980 Mar; 89(3):265-7. PubMed ID: 7388130.
    Abstract:
    It was shown in experiments on isolated gallbladders of rabbits that after 2 hours of incubation in Krebs solution, the concentration of Na+ and Cl- in mucous solutions decreased by 9.6 +/- 3.1 mM and 14.8 +/- 4.3 mM, respectively. Stereomicroscopy showed, under scraping of the epithelial layer of the gallbladder, a lucid intercellular fluid that could be collected in an amount of 2--4 mkl. The concentration of Na+ in this liquid was equal to 220.8 mM and that of Cl- amounted to 218.6 mM, the mean rate of the gallbladder fluid absorption being 43 mkl/h per 100 mg of the wet gallbladder wall weight. The concentration of the ions in intercellular fluid was inversly proportional to the volumetric epithelial flow rate. Na+ and Cl- concentration in the intercellular fluid was 20--25 mM higher than in incubation medium, with the absorption rate reaching 60 mkl/h per 100 mg of the wet gallbladder wall weight. The results obtained confirm the Diamond hypothesis of the existence of hyperosmotic area in the gallbladder wall.
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