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  • Title: [Syndromes of food hypermotivation in hyperactivity of lateral hypothalamic structures in rabbits].
    Author: Kryzhanovskiĭ GN, Khomulo PS, Kotov AV, Timofeeva OA.
    Journal: Biull Eksp Biol Med; 1980 Mar; 89(3):281-4. PubMed ID: 7388132.
    Abstract:
    In experiments on freely moving rabbits a focus of hyperactivity in the initiative centers of food motivation was created by means of blocking the inhibitory mechanisms in the lateral hypothalamus (LH) exposed to tetanus toxin (group I) or chronic electric stimulation (group II). The evoked syndromes were marked by intensity of food hypermotivation. The syndrome provoked by injection of tetanus toxin was characterized by an extremely rapid development, pronounced symptomatology of hyperphagia and severe progress. Concurrently, a pronounced epileptiform activity was recorded in LH, thus indicating the formation of a generator of pathologically enhanced excitation in the "pacemakers" of food motivation. The animals showed completely altered mechanisms of an adequate correction on the behaviour, depending on the results obtained. The syndrome provoked by chronic electric stimulation of LH was characterized by a slower formation and favourable course with a relatively weak epileptiform activity recorded in LH. Food hypermotivation was also demonstrated by the rabbits in the late periods after the commencement of electric stimulation; the adaptive pattern of the animals' behaviour remained unchanged. Occurence of the two syndromes of food hypermotivation is related to the formation of the excitation genertors that differ in the intensity of excitation they produce.
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