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  • Title: Synergistic effect of combined hyperthermia and a nitrosourea in treatment of a murine ependymoblastoma.
    Author: Thuning CA, Bakir NA, Warren J.
    Journal: Cancer Res; 1980 Aug; 40(8 Pt 1):2726-9. PubMed ID: 7388821.
    Abstract:
    The effectiveness of heat therapy in combination with 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea on a murine ependymoblastoma was investigated. Based on survival time and the number of survivors, whole-body hyperthermia (40 degrees) increased the therapeutic effectiveness of 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea. Heat alone did not modify the course of the tumor. Microscopic evidence of accelerated tumor destruction in hyperthermic mice was apparent within 24 hr of drug administration. A temporary drop in animal weight was observed with hyperthermia at the higher dose levels of drug. Mechanisms which may be involved in this synergism are discussed.
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