These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Hereditary motor endplate disease (med) of the mouse: observations on dissociated myogenic cells and their development in culture.
    Author: Jockusch H, Burkart W, Burger MM.
    Journal: Cell Tissue Res; 1980; 207(2):241-8. PubMed ID: 7388917.
    Abstract:
    Myogenic cells from mice homozygous for the lethal mutation "motor endplate disease" (med/med) were grown in culture. Like muscle cells taken from wild type (+/?) litter mates they fused to form myotubes which contracted, developed cross striations, and exposed acetylcholine receptors (AChR) on their surface. However, a decrease of 30% in the number of mononucleated cells per unit fresh weight of muscle was observed as early as 2--3 days postnatal, i.e., at least one week prior to the onset of physiological symptoms. Hence, in addition to influencing the functional maintenance of motor endplates, the med gene seems to control early events in muscle development.
    [Abstract] [Full Text] [Related] [New Search]