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  • Title: Assessment of regional blood flow by intravenous injection of 99m-technetium-pertechnetate.
    Author: Lindner P, Wolf F, Schad N.
    Journal: Eur J Nucl Med; 1980 Jun; 5(3):229-35. PubMed ID: 7389723.
    Abstract:
    A general method for computation of regional blood flow from time-activity curves obtained after intravenous injection of 99m-TC pertechnetate is presented. The method is based on the well-known principle of Meier and Zierler, but, it also considers the dispersion of an intravenously injected activity-bolus as well as the recirculation of the nondiffusible tracer. The problems arising from the use of a nondiffusible indicator concerning the partition coefficient lambda are discussed. This method of blood flow determination is adopted for measurements of cerebral blood flow and some first results are discussed.
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