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  • Title: Sex chromosome and chromatin examination in gynecology.
    Author: Ge QS, Huang LY, Tang MY, Zhang YW, Tang HS, Li JX, Zhou XT.
    Journal: Gynecol Obstet Invest; 1980; 11(1):17-36. PubMed ID: 7390274.
    Abstract:
    Sex chromosome and chromatin examinations with hormone determinations were done on 41 cases seen at the gynecologic clinic suspected of having sexual developmental abnormalities. 22 (53.7%) had genetic, gonadal or hormonal abnormalities, including ovarian dysgenesis 9 cases, superfemale 1 case, XY pure gonadal dysgenesis 4 cases, 3 of whom had already developed gonadal malignancy, pseudovaginal perineoscrotal hypospadias 1 case, androgen insensitivity syndrome 2 cases and congenital adrenal hyperplasia 3 cases. The values and limitations of sex chromosome and chromatin examinations as well as the prevention of gonadal malignancy are discussed.
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