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  • Title: Analysis of growth dynamics and the relationship to the fluctuations in alkaline phosphatase in two strains of cells of HeLa S3 derivation.
    Author: Brahmacupta P, Melnykovych G.
    Journal: In Vitro; 1980 May; 16(5):426-32. PubMed ID: 7390536.
    Abstract:
    Studies have been carried out to determine an association between glucocorticoid-induced changes in the pattern of growth and the fluctuations of alkaline phosphatase in two HeLa strains. The results showed that growth arrest in steroid-treated cells did not have the characteristics of density-induced growth inhibition. Alkaline phosphatase increased with increased cell density, the increase being greater than control in steroid-treated cells of the "inducible" strain (HeLa S3G, HeLa65) and less than control in the "suppressible" strain (HeLa S3K, HeLa71). Increased serum concentration in the growth medium (0 to 20%) caused an increase in alkaline phosphatase in S3G strain and a decrease in the S3K strain.
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