These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Comparison of cytosol estrogen and progestin receptor status in malignant and benign tumors and tumor-like lesions of human ovary.
    Author: Jänne O, Kauppila A, Syrjälä P, Vihko R.
    Journal: Int J Cancer; 1980 Feb 15; 25(2):175-9. PubMed ID: 7390646.
    Abstract:
    In an effort to gather more information regarding the human ovarian malignancies that respond favorably to hormone therapy, estrogen (ER) and progestin (PR) receptors in 21 malignant ovarian tumors were measured. The findings were compared with those in 29 benign tumors and 28 tumor-like ovarian lesions. Marked differences in steroid receptor distributions were observed between the 3 groups. Only 38% of the malignant tumors simultaneously contained measurable amounts of both receptors. The corresponding figure for the benign tumors was 76%. The malignant tumors were more frequently (29%) receptor-negative than the benign tumors (7%). The major difference in the tumor-like lesions was the high frequency (43%) of samples containing PR only, as compared with the other 2 groups. The respective concentrations of ER and PR were 114 + or - 42 and 148 + or 76 (malignant tumors), 71 + or - 34 and 132 + or - 32 (benign tumors), and 19 + or - 16 and 251 + or - 88 (tumor-like lesions). Of the malignant tumors, endometrioid carcinoma was characterized by a relatively high mean PR content. In undifferentiated carcinoma a high ER content was associated with a low PR concentration. Steroid receptor content was very similar in benign epithelial tumors with different histological properties.
    [Abstract] [Full Text] [Related] [New Search]