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  • Title: Peripheral resistances in acute myocardial infarction: the use of prazosine versus isosorbide dinitrate.
    Author: Costa PP, Permutti B, Fernandes P, Croce G.
    Journal: Int J Clin Pharmacol Ther Toxicol; 1980; 18(5):208-11. PubMed ID: 7390671.
    Abstract:
    Prazosine and isosorbide dinitrate have been studied in 15 patients with acute myocardial infarction complicated by heart failure. Prazosine at the first hour had a reduction of 39% of pulmonary capillary wedge pressure (PCWP), of 23% of systemic vascular resistences index (SVRI), of 20% of mean arterial pressure (AP). Isosorbide dinitrate at the first hour in a group of 7 patients had a decrease of SVRI by 19%, the cardiac index (CI) augmented by 23%, the PCWP fell by 15%, while in a group of 5 patients the drug had an increase of SVRI by 15%, a fall of 40% of PCWP and a slight decrease of CI.
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