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  • Title: Increased glomerular filtration rate and adrenocortical function in obese women.
    Author: Stokholm KH, Brøchner-Mortensen J, Hoilund-Carlsen PF.
    Journal: Int J Obes; 1980; 4(1):57-63. PubMed ID: 7390700.
    Abstract:
    Glomerular filtration rate (GFR) was measured in 16 obese women aged 28-48 years (overweight 65-110 per cent) and compared to GFR in 16 non-obese women of the same age and height. None of the women had signs of nephrourological disorders. GFR was determined from the total 51 Cr-EDTA plasma clearance measured by a simplified single-injection technique. In the obese women GFR (median value 129.0 ml/min) was significantly (P less than 0.002) increased by 24.6 per cent. The urinary excretion rate of 17-ketogenic steroids was increased in nine out of 14 obese women, but no correlation with GFR could be demonstrated. GFR in the obese women showed a significant positive correlation with the plasma cortisol concentration (rs = 0.77; P less than 0.01) and with the urinary excretion rate of free cortisol (rs = 0.78; P less than 0.01). Whether the correlation between the plasma cortisol concentration and the increased GFR in obese women is causal needs further investigation.
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