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  • Title: Morphine selectively influences macronutrient intake in the rat.
    Author: Marks-Kaufman R, Kanarek RB.
    Journal: Pharmacol Biochem Behav; 1980 Mar; 12(3):427-30. PubMed ID: 7393941.
    Abstract:
    Dietary self-selection of the three macronutrients, protein, carbohydrate and fat, was examined in male rats following the administration of three doses of morphine sulphate: 10 mg, 15 mg, and 30 mg/kg body weight. Intakes of all three macronutrients were suppressed in a dose-dependent manner for a two-hour period following morphine administration. Both protein and carbohydrate intakes remained suppressed for a six-hour feeding period after morphine injections. In contrast, animals increased fat intake during the final four hours of the six-hour feeding period resulting in an overall increase in fat intake.
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