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  • Title: Erythrocyte polyamine levels in rats with H4IIE hepatomas before and after radiation treatment.
    Author: Shipe JR, Savory J, Wills MR, Rowley R, Looney WB, Hopkins HA.
    Journal: Res Commun Chem Pathol Pharmacol; 1980 May; 28(2):329-42. PubMed ID: 7394327.
    Abstract:
    The concentration of the polyamines, spermidine and spermine associated with the erythrocytes of rats with H-4-II-E hepatomas increased with tumor growth. Following radiation therapy the erythrocyte spermidine and spermine levels decreased by 63 and 47% respectively. Six days after radiation treatment the erythrocyte polyamines had increased to the pre-treatment elevated levels. These data suggest that erythrocyte polyamine levels may be useful in assessing the response to therapy and in detecting the continued growth of the tumor in patients with malignant disease.
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