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  • Title: The effect of pyrrolizidine alkaloids (Senecio vulgaris) on the liver mixed-funcion oxidase system.
    Author: Eastman DF, Segall HJ.
    Journal: Toxicol Lett; 1980 May; 5(6):369-74. PubMed ID: 7394831.
    Abstract:
    A model system to detect the toxicity of pyrrolizidine alkaloids (PAs) was explored. Using the liver S-10 fraction, the effect of PAs on aniline hydroxylase and aminopyrine N-demethylase was examined. PAs were toxic to the aminopyrine N-demethylase enzyme system while exerting no toxicity on the aniline hydroxylase enzyme system.
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