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  • Title: The effects of tri-iodothyronine on the synthesis of mitochondrial proteins in isolated rat hepatocytes.
    Author: Nelson BD, Joste V, Wielburski A, Rosenqvist U.
    Journal: Biochim Biophys Acta; 1980 Jul 29; 608(2):422-6. PubMed ID: 7397193.
    Abstract:
    The effects of tri-iodothyronine on mitochondrial protein synthesis have been studied in in vitro labeled, isolated rat hepatocytes. Hepatocytes were isolated from hypothyroid rats or from hypothyroid rats 24 h after injecting a single, low dose of hormone (20-30 microgram/180-230 g body weight). Tri-iodothyronine increased translation on mitochondrial ribosomes by 2-3-fold, but, under our conditions, appears to have little or not effect on the general synthesis of cytoplasmically-translated mitochondrial proteins. Electrophoretic and fluorographic analysis indicated that tri-iodothyronine stimultes labeling of the four major mitochondrially-translated peptides. The hormone appears to act by inducing a general increase in translation/transcription of mitochondrially-synthesized peptides.
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