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  • Title: Platelet factor 4 regulates osteoclastic bone resorption in vitro.
    Author: Horton JE, Harper J, Harper E.
    Journal: Biochim Biophys Acta; 1980 Jul 03; 630(3):459-62. PubMed ID: 7397235.
    Abstract:
    Platelet factor 4, which inhibits collagenases derived from both human skin and granulocytic extracts, was found to block reversibly parathyroid hormone-stimulated 45Ca release from fetal rat bone in vitro. The inhibitory property was equally effective in both actively resorbing bones and in bones stimulated to initiate resorption.
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