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  • Title: Cell membrane phospholipids and their constitutent fatty acids in dividing and nondividing cells of Micrococcus lysodeikticus.
    Author: Johnson JH, Grula EA.
    Journal: Can J Microbiol; 1980 Jun; 26(6):658-63. PubMed ID: 7397608.
    Abstract:
    Changes occurring in the cell membrane of nondividing cells of Micrococcus lysodeikticus disIIp+ grown in the presence of the mucopeptide synthesis inhibitor D-cycloserine include (a) an increae in the relative amount of diphosphatidylglycerol with a concomitant decrease in the relative content of phosphatidylglycerol, (b) a small increase in the relative palmitic acid content of phosphatidylinositol, and (c) leakage of membrane components into the growth medium. Growth of the organism in the presence of both D-cycloserine and D-alanine (which prevents the effects of D-cycloserine on cell division and mucopeptide synthesis) prevents the above changes in the cell membrane, demonstrating that secondary damage to the cell membrane can occur as a rsult of inhibition in mucopeptide synthesis. Growth of the organism in the presence of D-cycloserine and pantoyl lactone prevents the leakage of membrne components and cell division inhibition. Possible relationships of these changes to cell division are discussed.
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