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  • Title: Effects of age and substrate on the circadian rhythm of liver tryptophan pyrrolase of female rats.
    Author: Patnaik SK, Sarangi SK.
    Journal: Cell Biol Int Rep; 1980 May; 4(5):471-7. PubMed ID: 7397788.
    Abstract:
    The level of tryptophan pyrrolase does not change significantly throughout the 24 hr cycle of the day in rat liver. Young and adult rats show a similar trend in the activity pattern of this enzyme. However, the activity pattern is altered in the post-reproductive rats. L-tryptophan induces liver tryptophan pyrrolase in rats of all the ages. Maximum induction is observed in the post-reproductive rats as compared to the young and adult rats. Further, the degree of induction of this enzyme by its substrate is also affected by the age of the rat.
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