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  • Title: Aging and sister chromatid exchange. V. The effect of post-embryonic development on mutagen-induced sister chromatid exchanges in mouse and rat bone marrow cells.
    Author: Nakanishi Y, Dein RA, Schneider EL.
    Journal: Cytogenet Cell Genet; 1980; 27(2-3):82-7. PubMed ID: 7398374.
    Abstract:
    Induction of sister chromatid exchanges (SCE) was examined as a function of post-embryonic development in C57BL/6J mice and Wistar rat bone marrow cells. At low concentrations of three different mutagens, cyclophosphamide, mitomycin C, and doxorubicin, induced SCE levels were not altered with post-embryonic development. However, at higher mutagen concentrations, SCE induction was significantly reduced in growing (3- to 8-week-old) animals when compared to mature (7- to 9-month-old) animals. Studies of 1- to 8-month-old mice at these high doses revealed that mutagen-induced SCE frequencies increase gradually during this period. These results suggest that with post-embryonic development, changes occur in cellular response to mutagen-induced DNA damage.
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