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  • Title: Identification of a macromolecular inhibitor of in vitro lymphocyte proliferation in human seminal plasma as bound spermine.
    Author: Curry MC, Hussain JI, Smith CJ, Allen JC.
    Journal: Eur J Cell Biol; 1980 Jun; 21(2):180-2. PubMed ID: 7398659.
    Abstract:
    The excluded fraction from Sephadex G-25 separation of human seminal plasma has been found to suppress lymphocyte transformation and DNA synthesis [7]. We have shown that most of its in vitro activity is due to contamination by spermine which binds tenaciously to, and co-elutes with the protein.
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