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  • Title: On the mode of action of ergometrine in the isolated dog coronary artery.
    Author: Sakanashi M, Yonemura KI.
    Journal: Eur J Pharmacol; 1980 Jun 13; 64(2-3):157-60. PubMed ID: 7398759.
    Abstract:
    Coronary vasoconstrictor responses to ergometrine were examined in spiral coronary arterial preparations of dogs. Either ergometrine or serotonin (5-HT) produced dose-dependent contractions of the strips. Methysergide significantly depressed the contractions induced by ergometrine or 5-Ht. Dihydroergotamine and phentolamine depressed constrictor responses to ergometrine, while phenoxybenzamine did not. The 5-HT antagonistic action of phentolamine was stronger than that of phenoxybenzamine. The results indicate that ergometrine may act on coronary arteries mainly through activation of 5-HT receptors.
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