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  • Title: Histamine H1-receptors labeled in vivo: antidepressant and antihistamine interactions.
    Author: Diffley D, Tran VT, Snyder SH.
    Journal: Eur J Pharmacol; 1980 Jun 13; 64(2-3):177-81. PubMed ID: 7398762.
    Abstract:
    3H-Mepyramine labels specific histamine H1-receptors in brains of mice after intravenous injection. The potencies of H1-antihistamines in reducing 3H-mepyramine binding in vivo correspond to their pharmacological activities and show parallels with their affinities for 3H-mepyramine binding sites in isolated brain membranes. Several antidepressants are potent in competing for 3H-mepyramine binding in vivo as well as in vitro.
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