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  • Title: Effect of haloperidol and pimozide on acetylcholine output from the cerebral cortex in rats and guinea pigs.
    Author: Casamenti F, Bianchi C, Beani L, Pepeu G.
    Journal: Eur J Pharmacol; 1980 Jul 25; 65(2-3):279-84. PubMed ID: 7398789.
    Abstract:
    The effect of haloperidol, pimozide and amphetamine on acetylcholine (ACh) output from the cerebral cortex was investigated in unanaesthetized, freely moving and urethane-anaesthetized rats and guinea pigs. Haloperidol (1 mg/kg i.p.) decreased ACh output only in the anaesthetized rats and increased it only in unanaesthetized guinea pigs. Pimozide (1 mg/kg i.p.) stimulated ACh output in unanaesthetized rats and guinea pigs and anaesthetized guinea pigs, but not in anaesthetized rats. Amphetamine (1 mg/kg i.p.) in all cases, stimulated ACh output. In rats with a septal lesion, the effect of amphetamine on ACh output was suppressed but that of pimozide was still present.
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