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  • Title: [Heart and brain tissue mitochondrial respiration and oxidative phosphorylation during cerebral circulatory hypoxia and in the posthypoxic period].
    Author: Kolotilova AI, Govorova LV, Kudriavtseva GV, Khari L, Makarov SA.
    Journal: Fiziol Zh SSSR Im I M Sechenova; 1980 May; 66(5):687-94. PubMed ID: 7398934.
    Abstract:
    Ischemia of the rat brain led to permanent increase in oxygen consumption, sharp phasic changes of oxydative phosphorylation, and fall of the P/O coefficient in the brain mitochodria which indicates a dissociation between respiration and phosphorylation. During the postischemic period all the parameters become normal. Oxygen consumption in the cardiac mitochondria is only enhanced in the early (15 min of circulatory hypoxia--CH) and late (72 hrs of CH) periods of CH. The oxydative phosphorylation is particularly low at 15 min and at 24-hr duration of CH. During the posthypoxic period the oxygen consumption is significantly enhanced but it drops lower than control level after 24-hr CH. The changes of oxydative phosphorylation occur in phases. The P/O coefficient is minimal in the posthypoxic period after the 15-min CH. Disturbances of oxydative metabolism seem lesser in the cardiac mitochondria. The changes occurring in the cardiac muscle during cerebral CH seem to underlie different signs of the cerebro-cardiac syndrome in brain pathology.
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