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  • Title: The breakdown of collagen by chondrocytes.
    Author: Jubb RW, Fell HB.
    Journal: J Pathol; 1980 Mar; 130(3):159-67. PubMed ID: 7400877.
    Abstract:
    The chondrocytes of pure articular cartilage from young pigs display collagenolytic activity when the cartilage is cultivated by an organ culture method in medium containing 5--10 IU retinol/ml. Breakdown of collagen occurs in all regions of the cartilage; in the thicker explants it is greatest and most frequent in those that contain the deepest zone composed of proliferating and hypertrophic chondrocytes; it is also very drastic in thin explants composed mainly of superficial fibro-cartilage.
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