These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Spasmogenic effects of L-ascorbic acid on the guinea pig isolated ileum preparation.
    Author: Terada M, Hayashi S, Hayashi E.
    Journal: Jpn J Pharmacol; 1980 Feb; 30(1):21-7. PubMed ID: 7401407.
    Abstract:
    The mechanism of actions of L-ascorbic acid (AA) on the guinea pig isolated ileum wasstudied. AA (neutralized, 10(-3) M) produced a stimulated motility (A effect) and a potentiation in acetylcholine (ACh)-induced contraction (B effect). The A effect showed a tachyphylaxis, and was inhibited by tetrodotoxin, atropine, adenosine, morphine, strychnine, Mg2+, papaverine and glucose- and Ca2+-free medium, but was stimulated by eserine. Thus, AA appears to have not only a direct myogenic effect but also a neurogenic effect by stimulating ACh release from intramural cholinergic nerves.
    [Abstract] [Full Text] [Related] [New Search]