These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Efficacy of a 12-hour sustained-release preparation in maintaining therapeutic serum theophylline levels in asthmatic children.
    Author: Kelly HW, Murphy S.
    Journal: Pediatrics; 1980 Jul; 66(1):97-102. PubMed ID: 7402798.
    Abstract:
    The purpose of this study was to determine whether a new sustained-release theophylline preparation TheoDur could maintain therapeutic serum theophylline levels in asthmatic children on a 12-hour dosage regimen. Twenty asthmatic children aged 6 to 18 years with a mean of 11.4 years who required continuous theophylline therapy for control of their asthma were enrolled in the study. Each patient's dosage was titrated to achieve a six-hour postdose serum theophylline level between 10 and 20 microgram/ml. The patients required a mean +/- SEM dose of 10.0 +/- 0.54 mg/kg every 12 hours which gave a mean +/- SEM six-hour postdose serum theophylline level of 15.65 +/- 0.72 microgram/ml. At the end of five days on this dosage, the patients were admitted and serum theophylline levels were determined every three hours for 24 hours. The mean +/- SEM difference between maximum and minimum serum theophylline levels (delta TL) for the group was 4.5 +/- 0.3 microgram/ml. There was not a significant difference in the delta TL between the two age groups (6 to 9 years, 4.5 +/- 0.5 microgram/ml and 10 to 18 years 4.5 +/- 0.4 microgram/ml). In conclusion, TheoDur will maintain therapeutic serum theophylline levels with minimal fluctuations in asthmatic children on a 12-hour dosing schedule.
    [Abstract] [Full Text] [Related] [New Search]