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  • Title: [Dopamine, noradrenaline and serotonin content in various parts of the hypothalamus in alloxan diabetes].
    Author: Baranov VG, Propp MV, Sokoloverova IM, Savchenko ON, Onegova RF.
    Journal: Probl Endokrinol (Mosk); 1980; 26(3):43-8. PubMed ID: 7403031.
    Abstract:
    In male rats with various forms of alloxan diabetes ("prediabetes", latent and manifest diabetes) there was revealed an increase in noradrenaline level in the anterior and the medial-basal hypothalamus. A rise of dophamine content was noted in the hypothalamus of these animals. Serotonin level fell in all the parts of the hypothalamus of males with "prediabetes". The level of immunoreactive insulin on fasting stomach was diminished in manifest alloxan diabetes, particularly in its severe forms. The data obtained suggest the importance of the feedback mechanism between the metabolic disturbances as a result of insulin insufficiency and the changes in the monoamines level in the hypothalamus. The role of certain parts of the hypothalamus in the regulation of insulin secretion is stressed.
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