These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Effect of mercuric chloride on microsomal enzyme system in mouse liver.
    Author: Abbas-Ali B.
    Journal: Pharmacology; 1980; 21(1):59-63. PubMed ID: 7403256.
    Abstract:
    The effect of mercuric chloride (2 mg/kg) on microsomal enzymes in mouse liver was investigated in phenobarbital- and 3-methylcholanthrene-induced hepatic microsomes. The metal caused an increase in total microsomal protein in noninduced controls, whereas no significant changes were observed in induced microsomes. Cytochrome P-450 was decreased in each case, which suggests that the metal may cause enzyme degradation. p-Nitroanisole O-demethylase was increased fivefold with both inducers. In addition, mercuric chloride increased the O-demethylase activity in relation to microsomal protein. The effect of the metal on ethylmorphine N-demethylase activity was slightly inhibitory.
    [Abstract] [Full Text] [Related] [New Search]